LEP and posterior cortical atrophy: There were significant within-group declines in chest skinfold thickness and BF% at 3 months, but not 6 months [33] and weight change was positively associated with changes in leptin and the leptin:adiponectin ratio, and negatively associated with IGF-1:IGFBP-3 ratio [34], which are proposed markers associated with PCa progression [45].