AKT1 and neoplasm: FGF14 expression, on the other hand, has been associated with tumor suppressor activity, which is downregulated in CRC tumor samples and in CRC cell lines as a result of high methylation of FGF14. Restoring FGF14 expression significantly reduces CRC tumor growth in vivo, associated with downregulation of PI3K-AKT-mTOR signaling in vitro [122].