The most common FGFR2 fusions in cholangiocarcinoma are with the BicC family RNA binding protein 1 (BICC1), the sickle tail protein homolog (KIAA1217), S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) and the coiled-coil domain containing protein 6 (CCDC6) [199,200]; however, more than 100 other fusion partners have been identified. The gene discussed is CCDC6; the disease is cholangiocarcinoma.