All these mutations belonged to eight known OVC-related genes (ARID1A, CDK12, ERBB2, MLH1, MSH2, MSH6, PIK3R1, PMS2) and seven known GBM-related genes (ATM, EGFR, MDM2, NF1, PDGFRA, PIK3CA, ROS1). This evidence concerns the gene MDM2 and glioblastoma.