TFEB and plasma cell myeloma: In multiple myeloma cells, FK866 triggered autophagic cell death via (i) the inhibition of PI3K/mTORC1 activity (a transcription-independent mechanism) and (ii) the inhibition of MAP kinase (MAPK), which permits nuclear translocation of the transcription factor EB (TFEB) that coordinates lysosomal biogenesis and drives the expression of autophagy-related genes [170,171].