In line with this notion, excision repair cross-complementation group 1 (ERCC1)-deficient NSCLC cells, a DNA-repair defective cancer model, showed reduced basal NAMPT and NAD levels, presumably as a result of chronic PARP1 activation, and FK866 treatment resulted in a catastrophic NAD drop and profound synthetic lethality in vitro and in vivo [185]. Here, PARP1 is linked to cancer.