In support of the above insights, combining FK866 with β-lapachone, an NQO1 substrate that generates ROS and exerts anticancer effects, was shown to cause dramatic NAD depletion and cytotoxic effects in NQO1-expressing pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC) cells [164,165,166]. Here, NQO1 is linked to non-small cell lung carcinoma.