Reward, euphoria, memory loss, altered vigilance, anxiety and cognitive deficit, proconvulsant, antinociceptive, cataleptic, hypolocomotion, and hypothermic effects of SCRAs, such as JWH-018, JWH-073, 5F-AMB, 5F-AB-PINACA, and Cumyl-4CN-BINACA, are mediated by CB1 receptor activation, as demonstrated in CB1 knock-out mice or by CB1-blocking agents [56,57,58,59,60,61,62,63,64,65]. This evidence concerns the gene CNR1 and Cognitive impairment.