Similarly, in a study in which the association of CLOCK polymorphisms with metabolic syndrome was investigated in 1100 participants in the Genetics of Lipid Lowering Drugs and Diet Network study, GG carriers of rs1801260 in the study population had significantly increased BMI, systolic blood pressure, fasting insulin level, and HOMA-IR compared with those with AG or AA genotype [15]. Here, INS is linked to metabolic syndrome.