PANX1 and neuropathic pain: Since Panx1 channels are phosphorylated at residue Y198 by a number of Gq-linked receptors, the authors suggested that Gq-linked receptors implicated in neuropathic pain, such as P2Y, histamine, and metabotropic glutamate receptors, could play a role in the activation of Panx1 channels in myeloid cells [106].