To assess the CNA changes in prostate tumors from men with Middle Eastern ancestry, we first focused on two known prostate-cancer-associated genes, NKX3-1 and MYC. Using FISH, we determined that 16% (7/42) of prostate tumors arising in men of Middle Eastern ancestry harbored an NKX3-1 deletion. Here, NKX3-1 is linked to prostate carcinoma.