To further investigate if CE and piceatannol have a synergistic effect with known inhibitors of the fusion step, including the fusion inhibitor T20, the CXCR4 inhibitor AMD3100, or the CCR5 inhibitor Maraviroc, we treated U373-CD4-CXCR4/U373-CD4-CCR5 cells with single drug or combined drugs during the infection of pseudotyped viruses pNL4.3ΔEnvLuc-HXB2/pNL4.3ΔEnvLuc-BAL for 2 h. This evidence concerns the gene CD4 and infection.