In these mice inoculated subcutaneously with H-2b tumor cells expressing OVA, OT-I CD8+ T cells vigorously proliferated, an effect abolished by DT treatment, indicating that DCs are essential for OT-I CD8+ T cell proliferation in response to the tumor cell-derived OVA peptide-H-2Kb in vivo [51]. The gene discussed is CD8A; the disease is neoplasm.