Coactivation of HER2 and PDGFRα caused by gene amplification or ligand overexpression has also been shown to activate the PI3K-AKT signalling and to reduce FGFR TKI-mediated MAPK signalling inhibition in an FGFR1-amplified lung cancer cell line [127,128]. This evidence concerns the gene FGFR1 and lung carcinoma.