Results from a genome-wide functional screen to identify genes whose overexpression confers resistance to FGFR inhibitors in a FGFR1-amplified NSCLC cell line identified known resistance drivers such as MET, EGFR, AKT and MAPK, but also novel resistance mediators such as members of the neurotrophin receptor pathway (NTRKs) and the TAM family of tyrosine kinases (TYRO3, MERTK, AXL) [131]. Here, FGFR1 is linked to non-small cell lung carcinoma.