FGFR2-SHTN1 has been previously identified in cholangiocarcinoma and has been linked to increased phosphorylation of PI3K/AKT and the mechanistic target of rapamycin kinase (mTOR) pathways in in vitro assays in NIH-3T3 and 293T-engineered cells [46,47]. This evidence concerns the gene FGFR2 and cholangiocarcinoma.