For example, antibody-based targeting of FGFR3 with R3Mab, an antagonistic anti-FGFR3 mAb capable of blocking ligand binding and receptor dimerisation, was tested in Ba/F3 mouse cells transfected with the cancer-associated mutants S249C, Y375C, R248C, G372C, and K652E [138]. The gene discussed is FGFR3; the disease is cancer.