KRAS and non-small cell lung carcinoma: Finally, using a high-throughput drug screen, Misale et al., identified several RTK inhibitors, including the FGFR TKIs ponatinib and infigratinib, exhibiting strong synergies with ARS-1620 in NSCLC cells lines and patient-derived xenograft (PDX) models harbouring mutant KRAS G12C [81].