A lesson learned from NSCLC patients with activating mutations in oncogenic drivers, such as EGFR, ALK and BRAF, underlines that treatment regimens which utilise sequential drugs with different mechanisms of action to target drug-sensitive clones, without allowing proliferation of drug-resistant cells, may be an effective strategy to minimize the evolution of drug resistance [145]. Here, EGFR is linked to non-small cell lung carcinoma.