The 414 upregulated genes were involved in 250 pathways including the spliceosome (KEGG:03040, 13), RNA transport (KEGG:03013, 13), neurodegeneration-multiple diseases pathways (KEGG:05022, 12), amyotrophic lateral sclerosis (KEGG:05014, 11), Toll and Imd signaling pathways (KEGG:04624, 10), and Shigellosis (KEGG:05131, 10). The gene discussed is TLR4; the disease is shigellosis.