Therefore, our results suggest that the transduced cells in the SVZ and CC may affect the nearby brain regions such as cerebral cortex and striatum through paracrine effects by the upregulation of MYRF and GDNF secreted from the activated NSCs and OPCs by OCT4, consequently inducing therapeutic effects of modest neuroprotection and functional recovery at the terminal stage of HD. Here, GDNF is linked to Huntington disease.