POU5F1 and Huntington disease: Namely, in situ expression of OCT4 in the SVZ increased the number of newly generated NSCs (Nestin+BrdU+ cells) and OPCs (NG2+BrdU+ cells) but not the number of newly generated neurons (βIII-tubulin+BrdU+ cells) and astrocytes (GFAP+BrdU+ cells) in HD mice at 6 weeks of age (Figure 2A–D).