AFP and hepatocellular carcinoma: For instance, Tomimaru et al. [132] demonstrated that miR-21 yielded an AUC of 0.773 with 61.1% sensitivity and 83.3% specificity in differentiating HCC from chronic hepatitis, and an AUC of 0.953 with 87.3% sensitivity and 92.0% specificity in differentiating HCC from healthy volunteers (in both cases superior to AFP).