MT1M or MT1G methylation:HCC vs. CLD: 90.0%/81.1%, 0.86HCC vs. healthy: 90.9%/83.9%, AUC = NRAFP alone: HCC vs. CLD: 56.0%/62.1% The gene discussed is MT1G; the disease is congenital secretory chloride diarrhea 1.