A specific form of large EVs expressing surface AnnexinV, EpCAM, ASGPR1, and CD133 was identified by Julich-Haertel et al. [165] as a marker able to distinguish HCC and cholangiocarcinoma from other cancer types, cancer-free cirrhotic patients, and healthy subjects. The gene discussed is ASGR1; the disease is hepatocellular carcinoma.