Lin et al. [133] demonstrated that a seven miRNAs classifier (miR-29a, miR-29c, miR-133a, miR-143, miR-145, miR-192, and miR-505) had a greater AUC compared to AFP in identifying small size and early-stage HCC, detecting also AFP-negative tumors. The gene discussed is AFP; the disease is hepatocellular carcinoma.