Circulating levels of LINC00152, XLOC014172, and RP11-160H22.5 were able to distinguish HCC patients from cirrhotics, chronic hepatis, and healthy subjects, with very high accuracy when combined with AFP (AUC of 0.986 for HCC vs. chronic hepatitis and 0.985 for HCC vs. healthy controls) [130]. This evidence concerns the gene AFP and hepatocellular carcinoma.