For example, using several empirical techniques, Neuhaus et al. [46] showed that 200 kHz AEFs at 1 V/cm (i.e., TTFields) affected a voltage-gated calcium channel (Cav1.2) in T98 human glioblastoma cells and produced apoptosis as well as G1 or S phase cell cycle arrest, breakdown of the inner mitochondrial membrane potential, and DNA degradation [46]. The gene discussed is CACNA1C; the disease is glioblastoma.