While acute psychological stress activates NF-kB in peripheral blood mononuclear cells [121,293,294,295,296,297], the use of mindfulness meditation reduced the expression of NF-kB in RCTs for breast cancer patients (n = 71) [295], lonely older adults (n = 40) [296] and older adults (n = 49) [297]. The gene discussed is NFKB1; the disease is breast cancer.