Eom et al. showed in melanoma that FRCs in tumor-infiltrated LNs may favor cancer invasion and progression through the secretion of soluble factors [20], and Gao et al. also showed in tumor-infiltrated LNs a decrease in FRCs and IL-7 secretion, leading to a declined number of T lymphocytes in LNs [34]. The gene discussed is IL7; the disease is melanoma.