PNPLA3 and chronic kidney disease: Recently, Mantovani et al. studied 101 post-menopausal T2D women, showing that the G/G genotype of rs738409 in the PNPLA3 gene was strongly associated with lower GFR CKD-EPI and a higher prevalence of CKD even after adjustment for age, duration of diabetes, haemoglobin A1c, HOMA-IR, systolic blood pressure, hypertension treatment and hepatic steatosis [56].