PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Similarly, the presence of the PNPLA3 rs738409 G allele was strongly associated with decreased GFR and intensification of a 24-hour urinary protein excretion in a sample of 142 overweight Italian children/adolescents with biopsy-proven NAFLD, independent of histologic severity, sex, age, measures of adiposity, blood pressure and HOMA-IR [55].