TET2 and atherosclerosis: To support this theory, Fuster and colleagues studied the effect of the expansion of TET2-deficient cells in atherosclerosis-prone, low-density lipoprotein receptor-deficient mice and observed that the partial reconstitution of the bone marrow with TET2-deficient cells was sufficient to generate clonal expansion, which was also associated with a marked increase in the size of atheromatous plaques and the increased secretion of pro-inflammatory cytokines such as IL-1β [167].