These include SNVs in genes that encode proteins that regulate epigenetic processes, such as TET2, DNMT3A, ASXL1, EZH2, and IDH1/2, as well as proteins implicated in the splicing of messenger RNA, such as SRSF2, SF3B1 and U2AF1 [12,106], with non-driver mutations detected by NGS in 53% and 75% of PV patients according to two recent studies [107,108]. Here, U2AF1 is linked to acquired polycythemia vera.