TP53 and acute myeloid leukemia: Indeed, a recent French study that investigated the time between diagnosis and leukemic progression in 49 patients with post-PV/ET AML (including 24 post-PV) observed that mutations in IDH1/2, RUNX1, and U2AF1 were associated with a shorter time to transformation, while mutations in the genes TP53, NRAS, and BCORL1 were associated with a longer time to transformation [187].