The most frequently mutated CHIP-associated genes are TET2, DNMT3A, ASXL1 (commonly referred to as the DTA genes), and JAK2. Recent studies have found an association between the accumulation of DTA SNVs and a higher risk for developing myeloid neoplasms, including BCR-ABL1-negative MPN and AML, as well as cardiovascular pathologies and a higher prevalence of developing derived complications from diabetes [119]. Here, JAK2 is linked to acute myeloid leukemia.