Other examples of well-known pro-inflammatory species with links to CRC are colibactin-producing Escherichia coli, which enhances inflammation and the production of reactive oxygen species (ROS) in tumors in early-stage CRC [56], and enterotoxigenic Bactoroides fragilis, which mediates inflammation through the Th17 response and NF-κB activation, thus inducing myeloid cell-dependent distal colon tumorigenesis [57]. The gene discussed is NFKB1; the disease is colorectal carcinoma.