RNF43 and cervical squamous intraepithelial neoplasia: Interestingly, five out of six GC cases with oncogenic TP53 mutations such as p.Thr125Arg, p.Gln144His, p.His193Arg, p.Gly244Profs*16, and p.Glu286Lys in the DNA-binding domains had other somatic mutations of different genes, including ERBB2, KRAS, MYC, and RNF43. Consistent with frequent TP53 mutation, elevated expression of TP53 and aneuploidy were presented in the chromosomal instability (CIN) subtype [25].