Additionally, USP10 is one of the Skp2 deubiquitylation enzymes, which modulates the Skp2/Bcr-Abl axis by stabilizing Skp2 in chronic myeloid leukemia (CML) and thus promotes cell proliferation in CML cells. Here, SKP2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.