Skp2 is implicated in the ubiquitination of cyclin D1 and cyclin D1 levels are negatively correlated with Skp2 since expression of Skp2 antisense induces accumulation of cyclin D1, and defective cyclin D1 degradation within the SK-UT-1B uterine tumor cell line are often rescued by stable transfection of Skp2. Here, CCND1 is linked to tumor of uterus.