Over-expression of family with sequence similarity 60A (FAM60A) in A549 cisplatin-resistant cells led to Skp2 upregulation and enhanced cisplatin resistance in cancer cells, along with elevated MDR1 expression, and decreased caspase 3, cleaved-caspase 3, and caspase 8 expression, and further inhibited cancer cell death. This evidence concerns the gene CASP3 and cancer.