A previous study showed that SIRT2 regulates the expression of several tyrosine kinase receptors, including EGFR (epidermal growth factor receptor), and affects downstream signaling of SRC-ERK (proto-oncogene tyrosine-protein kinase Src-extracellular signal-regulated kinase) [9], which plays a prominent role in the proliferation and resistance of melanoma to certain drugs [26,27]. This evidence concerns the gene SIRT2 and melanoma.