On the other hand, Perez et al. outlined that NPY has a higher expression in superficial melanoma or lentigo maligna, while melanoma with low levels of NPY was characterized by intense cell proliferation, numerous peritumoral mast cells, and low expression of E-cadherin, concluding that high NPY expression in melanoma is associated with a better prognosis [253]. This evidence concerns the gene NPY and melanoma.