POMC and neoplasm: Moreover, recent studies highlighted the patterns of hormone expression associated with the CRH-POMC axis in various skin tumors [157] and enzyme-linked immunosorbent assay (ELISA) has been used to assess the production of CRH, adrenocorticotropic hormone (ACTH), and alpha-melanocyte-stimulating hormone (α-MSH) in tumor cell lines and primary keratinocytes.