Together, our data showed that, although IQGAP1 is necessary for HPV-induced PI3K signaling in normal epithelia, it did not influence markers related to HPV infection or HPV-associated carcinogenesis, consistent with the previous result that IQGAP1 did not reduce HPV-associated HNSCC (Figures S4 and S5). This evidence concerns the gene PIK3CA and head and neck squamous cell carcinoma.