IQGAP1 and invasive carcinoma: However, the loss of IQGAP1 did not cause a significant reduction in the incidence of invasive carcinoma (Iqgap1+/+ vs. Iqgap1−/−, p = 1; Iqgap1+/+K14E6E7 vs. Iqgap1−/−K14E6E7, p = 0.26, two-sided Fisher’s exact test).