IQGAP1 and squamous cell carcinoma: In terms of histopathologic examination, HPV16 transgenic mice developed significantly higher incidences of invasive squamous cell carcinoma than non-transgenic groups (Figure S4D, Iqgap1+/+ vs. Iqgap1+/+K14E6E7, p < 0.0001; Iqgap1−/− vs. Iqgap1−/−K14E6E7, p < 0.0001, two-sided Fisher’s exact test).