BRCA1 and neoplasm: Figure 2 shows the relative expression of ATM and BRCA1 in tumor versus adjacent non-tumor tissues. The expression of ATM (Figure 2A) and BRCA1 (Figure 2B) was downregulated (tumor/non-tumor < 1) in 80 and 68 cases of HNC, respectively. In contrast, the expression of ATM (Figure 2C) and BRCA1 (Figure 2D) was not decreased in the HNC specimens of The Cancer Genome Atlas (TCGA) cohort, which did not expose to BQ.