Moreover, whereas the insulin sensitizer agent metformin did not show a significant effect on LDL serum levels in T2DM patients, the combination of metformin and CoQ10 led to an amelioration of lipid profile and glucose indices, through the reduction of fasting blood glucose, fasting serum insulin and HbA1c along with a significant increment in the insulin sensitivity compared with the baseline [36]. The gene discussed is INS; the disease is type 2 diabetes mellitus.