A novel immune checkpoint T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (TIGIT), which always co-expresses with PD-1 on NK and T cells and symbolizes a more exhausted status, plays pivotal roles in the adaptive anti-tumor immunity by ligation with its major ligand poliovirus receptor (PVR) [2,3]. The gene discussed is PVR; the disease is neoplasm.