NFKB1 and amyotrophic lateral sclerosis: Conversely, FABP7 overexpression can directly promote a nuclear factor-kappa B (NF-κB)-driven pro-inflammatory response in astrocytes of mice with amyotrophic lateral sclerosis and can ultimately reduce motor neuron survival [42], whereas FABP7 knockdown in the developing brain can increase the proportion of neurons [43,44].