Therefore, due to FAP expression on various cell types, including GBM cells, stromal cells, endothelial cells and pericytes, within the GBM microenvironment, FAP-targeted therapy could be extended to GBM, where FAP expression is limited to tumor cells, as well as their supporting vascular networks and stromal cells within the microenvironment, which play important roles in tumor progression. The gene discussed is FAP; the disease is glioblastoma.