In GBM, a recent study discovered that the invasiveness of GBM was associated with the proximity of fibrinogen to MMP-2 and MMP-9 [35], which suggests that the proteolytic process through MMP may also play an important role in GBM, and more studies are still needed to support the function of FAP and its substrates in GBM. This evidence concerns the gene MMP2 and glioblastoma.