TG and hypothyroidism: Patients with clinically overt hypothyroidism have impaired levels of free thyroid hormone, with TSH concentrations that are markedly high, which usually obliterate the detection of the daily secretion of the hormone, whereas patients with subclinical hypothyroidism, in whom free thyroid hormones are still in the normal range and TSH levels are slightly increased above the normal range, may show a daily secretion pattern of the hormone that is still sustained [30,39,73].