Even though IL-27 and IL-29 are linked to the instigation of antiviral protein production, our Pso patients did not develop any severe symptoms or complications due to COVID-19, suggesting that other proinflammatory cytokines may contribute to the cytokine milieu balance in psoriasis inflammation and thus that modulation of IL-27 does not lead to an increased risk of virus infection in these patients. Here, IL27 is linked to psoriasis.