PPARGC1A and Insulin resistance: Alternatively, Mutlur Krishnamoorthy, and Carani Venkatraman (2017) [26] showed that treating palmitate-induced insulin resistance L6 myotubes with 750 mM quercetin or 75 μM naringenin for 16 h could improve glucose homeostasis and mitochondrial bioenergetics by enhancing GLUT4 translocation, as well as increasing AMPK phosphorylation, and SIRT1 and PGC1α expression.