A phase II study in selected FGFR-altered CCA patients that progressed after chemotherapy showed an ORR of 14.8% (18.8% FGFR2 fusions only) and a disease control rate (DCR) of 75.4% (83.3% FGFR2 fusions only) [62]. Here, FGFR2 is linked to cholangiocarcinoma.