Based on the results of the FIGHT-202 trial, which showed a 35.5% overall response rate (ORR) in 38 patients with FGFR2 fusions or rearrangements, three with a complete response and 35 with partial responses [61], the FDA approved in April 2020 this drug for chemotherapy-refractory CCA patients with FGFR2 rearrangements or fusions. The gene discussed is FGFR2; the disease is cholangiocarcinoma.