Furthermore, transcriptome studies on murine models of AD, supported by microscopy analyses on human post-mortem brains, identified a neuroprotective subset of disease-associated microglia (DAM), whose full activation depends on a transmembrane receptor protein that controls microglial activity and survival: the triggering receptor expressed on myeloid cells 2 (TREM2) [59]. Here, TREM2 is linked to Alzheimer disease.