TXNRD2 and cancer: Moreover, an influence of selenoprotein polymorphisms on the risk of breast (Gpx1, SelF, SelP) or colorectal (Gpx4, TrxR1, and TrxR2, SelP, SelF, and SelS) cancer was also found, which could indicate their important role in the etiology of these types of cancer [81].