A study showed that, in gastric cell lines, exosomal Ribosomal Protein S3 (RPS3) secreted by cisplatin-resistant tumor cells could be taken up by cisplatin-sensitive cells and thus become chemoresistant (through activation of the PI3K-Akt-cofilin-1 signaling pathway) [76]. The gene discussed is RPS3; the disease is neoplasm.