PROS1 and obesity due to melanocortin 4 receptor deficiency: Moreover, TRF may play a role in the pathophysiology of obesity through the modulation of the expression of protein chaperones (e.g., heat-shock proteins) and growth factors (e.g., brain-derived neurotrophic factor) that lead both to less oxidative damage and higher stress resistance [43], and, consequently, improved adipose tissue signaling and a lower increase of fat storage [44].