INS and coronary artery disorder: Although reducing the feeding time window during the day may be beneficial, shifting food intake to the darkest hours can partially reverse circadian rhythms and have null, if not detrimental, effects on metabolic outcomes; there is a large body of scientific literature showing that individuals consuming a larger daily caloric intake during the evening are more likely to be overweight and obese [55,56,57,58,59,60]; moreover, other studies showed that nocturnal eaters had an increased coronary heart disease risk [61] and reduced insulin sensitivity assessed by HOMA-IR index [62].