As such, the normalization of ERK and AKT phosphorylation status in KO mice have frequently been associated with the correction of the improper translational rate, LTD and behavioral phenotypes; thereby establishing measurements of ERK and AKT activation status as one of the most potent biomarkers of therapeutic efficiency for FXS [44,45,109,110,126]. Here, AKT1 is linked to fragile X syndrome.