BRCA1 and ovarian cancer: Mutation or complete loss of the BRCA1 and BRCA2 genes, often referred to as driver mutations, are considered to be the first evolutionary steps during the development of a high percentage of breast and ovarian cancers, due to the key role of BRCA proteins within the maintenance of genome stability, achieved by multiple mechanisms [4,5,6,7] such as homologous recombination, a mechanism of DNA double-strand break repair [8,9,10,11].