In MCF-7/ADR and MCF-7/Akt (MCF-7 cells that constitutively express active Akt), the downregulation of phospho-Akt by SZ-685C led to a dose-dependent (2–8 μM) decrease in phospho-Bad and Bcl-xL protein expression, which promoted cancer cell apoptosis [66]. Here, AKT1 is linked to cancer.