We examined the association between breast cancer characteristics and genetic variants in GCR/NR3C1 and genes downstream of GCR activation: FKBP5, Sgk1, IL-6, ADIPOQ, LEPR, SOD2, CAT, and BCL2. To investigate GCR protein expression and subcellular localization, we used tissue microarray arrays (TMA) and multispectral digital imaging. The gene discussed is LEPR; the disease is breast carcinoma.