KCNH2 and tuberculosis: In a murine model of TB, TBAJ-876 demonstrated activity similar to BDQ at the same dose, with a lower calculated lipophilicity (clogP) of 5.15, higher IC50 value against hERG (>30 μM), and, in most cases, higher Cl values in human microsome (2 μM/min/mg protein) [78].