Subsequently, advanced studies that evaluated the PK of TBAJ-876 and TBAJ-587 (discussed below) against BDQ demonstrated lower MICs in clinical isolates of Mtb, efficacy against murine TB at lower exposures, lower potency against hERG, predicted higher human Cl, and an acceptable safety margin, based on the safe exposure in rats [78]. The gene discussed is KCNH2; the disease is tuberculosis.