Refractory R-HTN (rfR-HTN) refers to patients with elevated office BP values while on treatment with five or more antihypertensive drugs, including a long-acting thiazide-type diuretic, such as indapamide or chlorthalidone, or a mineralocorticoid receptor antagonist (MRA), such as spironolactone [5] (Figure 1). Here, NR3C2 is linked to hypertensive disorder.