DM (HR, 1.82; 95% CI, 1.26–2.63; p = 0.001), DN (HR, 1.67; 95% CI, 1.17–2.38; p = 0.005) and HD introduction in late period (HR, 2.41; 95% CI, 1.48–3.93, p < 0.001), CRP > 0.3 (HR, 2.55; 95% CI, 1.80–3.62; p < 0.001), Kt/V (K dialyzer clearance of urea, t dialysis time, V volume of distribution of urea) <1.2 (HR, 1.97; 95% CI, 1.39–2.79, p < 0.001) and URR < 65 (HR, 2.61; 95% CI, 1.80–3.78, p < 0.001) were significant risk factors for stroke and/or death events. The gene discussed is CRP; the disease is diabetes mellitus.