The various classifications of population-responding ICIs are mainly attributed to tumor microenvironments (TMEs), especially the composition and quantities of tumor-infiltrating lymphocytes (TILs), as well as numerous factors that independently predict clinical response to ICIs, including PD-L1 expression, tumor mutation burden (TMB), neo-antigen genotype, immune cell exhaustion, and disordered expression levels of cytokines [6,7,8,9,10]. The gene discussed is CD274; the disease is neoplasm.