For example, knockdown or inhibition of MTAP (S-methyl-5′-thioadenosine phosphorylase) by shRNA or treatment with Methylthio-DADMe-Immucillin-A (MTDIA) blocks androgen sensitive prostate cancer growth in vivo, suggesting this methionine salvage pathway is important for PCa cell survival [114]. This evidence concerns the gene MTAP and posterior cortical atrophy.