ELAVL1 and skin neoplasm: For example, binding of HuR, an AU-rich RNA binding protein, to AU-rich elements in the 3′ untranslated region (UTR) of ODC transcripts stabilizes ODC mRNA in models of skin cancer and in KRas-transformed cells, and this is partly dependent of mTORC1 signaling, as treatment with the mTORC1 inhibitor rapamycin, or siRNA targeting mTOR, destabilizes ODC mRNA by impairing HuR binding [58].