In contrast, depletion of polyamines by knockout of Odc or treatment with an ODC suicide inhibitor coined α-difluoromethylornithine (DFMO) [26], markedly impairs tumor development in Eμ-Myc mice, a validated model of MYC-driven B cell lymphoma [27] and in MYCN-driven neuroblastoma [28,29]. Here, ODC1 is linked to B-cell non-Hodgkin lymphoma.