Niclosamide promoted LRP5/6 degradation [156], Wnt receptor Fzd1 endocytosis [157], downregulation of Dvl2 proteins, and inhibition of Wnt3A-stimulated β-catenin stabilization and TCF/LEF reporter activity [157,158] as well as enhanced cytotoxicity in all the patient derived tumor spheres. The gene discussed is FZD1; the disease is neoplasm.