Moreover, considering that ELTD1 regulation by the VEGF ligand has been established [24], VEGFR2 association with ELTD1 in glioma was studied using targeted antibody inhibition, proving again that ELTD1 has a key role in angiogenesis, both in vitro and in vivo [18,24]. The gene discussed is ADGRL4; the disease is central nervous system cancer.