By analyzing the alterations of ELTD1 genetic sequence in different cancers usingcBioPortal for cancer genomic database [76], in Figure 4 it can be observed that ELTD1 alterations have a very low frequency in several malignancies such as glioblastoma, ocular melanoma, renal cell carcinoma, colorectal cancer, thyroid cancer, and ovarian cancer, which may suggest that mutation levels are not influencing the tumor evolution, even though high levels of its expression may indicate the presence of the respective malignancy [18,76,77]. This evidence concerns the gene ADGRL4 and renal cell carcinoma.