ABCG2 and Andersen-Tawil syndrome: OATP1A1 is incorporated in all the models, while OATP1B3 is only considered in the models of Li et al. and Morse et al. Efflux processes are implemented in the gut wall through P-gp and BCRP only in the model of Zhang, and a canalicular efflux process mediated by BCRP is assessed only in the model of Duan et al. As stated previously, the roles of P-gp [50] and BCRP [35] in the PK of ATS have been demonstrated in vivo, thus, the PBPK models of ATS should incorporate them to best characterize its absorption and enterohepatic recirculation.